Paint.Net 5.0 users find two graphics controls in the Settings. An added benefit of the change is that the 'quality of rendering and the accuracy of colors' is greatly improved. Besides user interface accelerations, most 'adjustments and effects' use the GPU now in the new release. In Paint.Net 5.0, core user interface parts, including the history and layers windows, the ruler, the image list and the Curves and Levels adjustment user interfaces make use of GPU acceleration. The new version expands GPU acceleration work that started in Paint.Net 4.0. One of the main improvements is performance in the new version of Paint.Net.

Paint.Net 5.0 is a major new release that 'has many major performance improvements, new features including pressure sensitivity for pens and drawing tablets, and a brand new effect plugin system with GPU rendering support' according to the author of Paint.Net.

Older versions of Windows are no longer supported, and users who still run these devices may keep on running 4.x instead. The new version runs only on 64-bit versions of Windows 10 and 11. Paint.Net 5.0 is a new major release that makes changes to the program's system requirements.

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